05/2023 – congratulations to Norbert for his ZonMW off road grant to explore circRNA in liquid biopsy using nanopore sequencing! https://www.zonmw.nl/nl/nieuws/19-innovatieve-ideeen-krijgen-een-road-subsidie-voor-baanbrekend-onderzoek
11/2022 – Interested in cell-free DNA and liquidbiopsy? Want a ride to catch up on the recent progress related to the biology of cfDNA? Ask for hitchhiking! Here is a new review from the lab. https://doi.org/10.1093/noajnl/vdac066
08/2022 – grateful to have been awarded a research funding from the KWF (Dutch Cancer Society) to develop innovative liquid biopsy approaches for the detection of brain cancers.
04/2022 – today we released FrEIA, a package developed by Norbert Moldovan for the reproducible analysis of cfDNA fragment-end composition and diversity. https://github.com/mouliere-lab/FrEIA
03/2022 – welcome to Francesco, visiting PhD student from the Demichelis lab (Trento University).
03/2022 – a careful consideration of pre-analytical and physiological conditions is critical for cell-free DNA analysis. Ymke recently published a comprehensive examination of potential bias in fragmentomic data for these parameters. Congrats! https://doi.org/10.1093/clinchem/hvac029
02/2022 – welcome to our new undergraduate students: Adhini, Nils and Ignas!
12/2021 – delighted to share our new work published in Genome Research redrawing cell-free DNA structure in healthy and cancer individuals. https://genome.cshlp.org/content/early/2021/12/20/gr.275691.121.abstract
11/2021 – happy to share a new review published in collaboration with Richard Mair (University of Cambridge) summarising the recent progress in liquid biopsy for glioma analysis. https://doi.org/10.1038/s41416-021-01594-5
10/2021 – we published a new pre-print in MedRxiv https://doi.org/10.1101/2021.09.30.21264176
09/2021 – we published a new pre-print in BioRxiv https://doi.org/10.1101/2021.09.17.460828
08/2021 – we co-authored an article in Journal of Molecular Diagnostics in collaboration with the Ylstra lab from the Cancer Center Amsterdam. More information here: https://doi.org/10.1016/j.jmoldx.2021.08.008
08/2021 – New pre-print in MedRxiv https://doi.org/10.1101/2021.08.11.21261907
07/2021 – We published an article in EMBO Molecular Medicine. More information here: https://www.embopress.org/doi/full/10.15252/emmm.202012881 The article has been highlighted in the Telegraph (https://www.telegraph.co.uk/science/2021/07/23/brain-tumours-detected-urine-test-first-time/) and by the University of Cambridge (https://www.cam.ac.uk/research/news/scientists-can-detect-brain-tumours-using-a-simple-urine-or-blood-plasma-test)
07/2021 – New pre-print in MedRxiv https://doi.org/10.1101/2021.06.01.21258171
07/2021 – New pre-print in MedRxiv https://doi.org/10.1101/2021.07.22.21260982
01/2021 – Jip Ramaker joined the lab as technician !
08/2020 – Norbert Moldovan joined the lab as postdoctoral computational biologist !
12/2019 – We have received a KWF research grant to improve our understanding of cell-free DNA fragmentation and how to leverage this information to improve the detection of early stage cancer. More information here: https://www.amsterdamresearch.org/web/instituut-1/nieuws/tonenop/-6.3-million-euros-kwf-funding-for-amsterdam-umc-cancer-center-.htm
10/2019 – We published a review in Cancer Cell. More information here: https://www.cell.com/cancer-cell/pdf/S1535-6108(19)30386-1.pdf
09/2019 – Trang Vu, a visiting PhD student from Rowan University, NJ, USA, is joining the lab for 6 months after receiving a competitive GIRE fellowship!
09/2019 – Ymke has been accepted to follow the Cold Spring Harbor Advanced Sequencing course. Congrats!
09/2019 – pre-print released on BioRxiv: how to detect ctDNA in the plasma and urine of glioma patients using personalised sequencing. https://www.biorxiv.org/content/10.1101/758441v1
06/2019 – Dries Boers joined the lab as bioinformatician !
01/2019 – Ymke van der Pol joined the lab as a PhD student !
11/2018 – We have published 3 research articles in Science Translational Medicine, Cancer Research and EMBO Molecular Medicine. Read this summary published in the New Scientist. https://www.newscientist.com/article/2184604-blood-test-can-spot-dna-from-eight-different-types-of-cancer/ and here https://www.genengnews.com/insights/breaking-new-ground-in-liquid-biopsy/